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Licensing Information

Intellectual Property Technology Report

Licensing

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Table of Contents

Summaries

Baculovirus Cloning, Biopesticides & Related Products (PDF)

This application discloses a pseudotyped baculovirus comprising a deletion, inactivation or reduction from regulation of a baculovirus envelope protein gene, and is engineered to express an envelope protein from another virus or cell, or another protein or molecule that facilitates entry of said baculovirus into a non-host cell, or provided with a heterologous envelope protein or another protein or molecule that facilitates entry of said baculovirus into a non-host cell by other suitable means. Such baculoviruses can be used to efficiently deliver genes to mammalian cells or organisms, and such genes can be expressed either from the baculovirus genome, or integrated into the mammalian cell genome, and can be used for expression of proteins such that purification of secreted or other protein products does not require removal of contaminating baculovirus particles or baculovirus envelope proteins.

Banana Proteins And Regulatory Elements (PDF)

This patent discloses isolated and purified genes, which are differentially expressed during banana fruit development, and the protein products of these genes. The disclosure further provides DNA regulatory elements which are differentially expressed during banana fruit development, chimeric genes comprising these DNA regulatory elements operably linked to heterologous DNA molecules, and plants transformed with the chimeric genes, providing for controlled expression of the heterologous DNA molecules during the development and ripening of the fruit of the plants, or in response to exogenous ethylene signals in the plants.

Canine Parvovirus (PDF)

This patent discloses a recombinant subunit vaccine for protecting dogs against infection caused by canine parvovirus comprising VP-2 protein produced during replication of a recombinant baculovirus in insect tissue culture cells or insects that are a permissive host for the replication of selected baculoviruses.

Genetic Engineering in Cyanobacteria (PDF)

This patent discloses a procaryotic microorganism and a method for its production is provided wherein the microorganism contains at least one stable foreign DNA portion in the chromosome. The disclosed microorganisms and their progeny are substantially free of genetic rearrangement involving the foreign DNA. In a preferred embodiment, cyanobacteria are employed. The microorganisms are produced by introducing into the cell an insertion vehicle that contains foreign DNA ligated between two portions of DNA homologous to adjacent portions of the recipient's chromosome.

Genetically Engineered Plants, Gene Expression, Related Products (PDF)

This application discloses novel nucleic acid molecules encoding SA-binding proteins involved in SA-mediated disease resistance responses are disclosed. Methods of use of the nucleic acid molecules and proteins of the invention are also provided.

High Density Insect Rearing System, Per Os Infection (PDF)

This patent discloses methods and apparatus for rearing insects. Information concerning the physical and dietary needs of the insect as well as behavioral characteristics are utilized to maximize the number of larvae reared per unit surface area of diet and per unit of rearing area while minimizing the amount of labor and materials required. An enclosed rearing unit is provided which can be located within an appropriate environment for rearing the insects. There are three sections within the rearing unit: 1) a diet space, 2) a larval space, and 3) a frass space. The diet space includes an appropriate diet medium for the insects. The larval space is located below the diet space and includes a series of vertical partitions perpendicular to and in contact with or nearly in contact with the diet medium such that the insect larvae are able to disperse themselves over the partitions. The frass space is located below the larval space such that any frass collects within the frass space as it is produced and does not interfere with the larval space or the diet space. The rearing system can further include an emergence pan including an outlet for allowing emerging adults to enter an oviposition cage. The emergence pan replaces the frass collection pan when all of the larvae have pupated. The rearing unit is turned upside down such that the emergence pan is located above the larval space and the diet space.

Insect Cell Lines, Protein Expression And Related Processes (PDF)

This application discloses cell lines commonly used for protein expression, which are engineered to express genes that encode suppressors of apoptosis (SA) (cell lines Sf9P35AcV5-1 and Sf9P35AcV5-3). Insect cell lines expressing these SA genes are resistant to apoptosis or programmed cell death, and express certain recombinant proteins at increased levels. These cell lines also have increased resistance to many types of stress. Because some of the SA proteins inhibit apoptosis in a wide spectrum of organisms, these genes may be inserted into other plant or animal cell lines for a variety of purposes involving resistance to apoptosis or resistance to stress.

Plant-Defense Related Technology (PDF)

One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid molecules which are complementary thereto. Expression vectors, host cells, and transgenic plants that include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The various nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant, make a plant hypersusceptible to colonization by nonpathogenic bacteria, modify a metabolic pathway in a cell, cause eukaryotic cell death and treat a cancerous condition, as well as inhibit programmed cell death.

Plant-Expressed Vaccines And Related Products (PDF)

The present invention provides for processing methods that preserve pharmaceutical proteins expressed in plants. Herein raw plant tissue is reduced to a stable homogenate without significant loss of protein or pharmaceutical potency. The homogenate can be used directly for pharmaceutical purposes without the need to further extract, purify, or precipitate the pharmaceutical protein. The present invention further provides a method of effective immunocontraception for animal and human application. Methods are disclosed for producing transgenic plants or plant cells which express contraceptive proteins, and which can be delivered whole, in part, or after processing, to an animal to cause a contraceptive effect in the target species.

Method Of Protecting Biological Materials In The Dry State (PDF)

This patent discloses a method for protection of biological materials from the stresses of air-drying and also from destructive reactions, such as oxidation and free-radical attack, which degrade the materials during long-term storage. The method involves drying the materials, which may contain potentially destructive agents such as free-radical generators or reducing sugars, in the presence of a vitrifying substance, and under conditions that allow the protective substance to become vitrified.

For more information

Please contact Paul Debbie at ppd2@cornell.edu or by phone at (607) 254-8729 or 254-1220.

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