Ji-Young Lee
Research Summary
The Lee Lab focuses on understanding the gene regulatory network in the vascular tissues using Arabidopsis root as a model system. In particular, the lab is trying to understand the developmental role and underlying transcriptional regulatory networks in the procambium/cambium. The procambium is localized in the boundary of xylem and phloem and stays quiescent. However, by unknown developmental cues it will start to divide and generate more xylem and phloem cells. This meristematic tissue, the cambium, leads lateral growth of roots and stems.
Cell type specific transcript profiling using microarray technique combined with cell sorting has generated the expression map in the root covering 17 cell types. Furthermore, the expression profiling in developing cambial/procambial tissues is in progress. Based upon the genome-wide expression data, procambium/cambium specific transcription factors will be identified and their developmental functions and regulatory networks will be systematically characterized by functional genetics and genomics approaches.
With the large scale gene expression data, the lab aims to understand the core gene regulatory network in the procambium and the cambium, and its evolution in the vascular plants.
Publications
Lee, J-Y, P.N. Benfey. 2007. Root Apical Meristems. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd. Chichester 0:
Brady, S.M., Orlando, D., Lee, J-Y., Wang, J., Koch, J., Dinneny, J.R., Mace, D., Ohler, U. and P.N. Benfey. 2007. A high resolution root expression map predicts cellular function and reveals novel expression patterns. Science (In Press) 0:
Mummenhoff, K., P. Linder, N. Friesen, J.L. Bowman, J-Y. Lee, J-Y. and A. Franzke. 2006. African species of Lepidium (Brassicaceae) contributed via hybridization to the origin of Australian/New Zealand species. In: S.A. Ghazanfar & H.J. Beentje (eds), Taxonomy and ecology of African plants, their conservation and sustainable use. Royal Botanic Gardens, Kew 0: 291–308
Lee, J-Y., Colinas, J., Wang, J.Y., Mace, D., Ohler, U. and P.N. Benfey. 2006. Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots.. Proc. Natl. Acad. Sci. USA 103: 6055-6060
Mace, D.L., Lee, J-Y., Twigg, R.W., Colinas, J., Benfey, P.N. and U. Ohler. 2006. Quantification of Transcription Factor Expression from Arabidopsis Images.. Bioinformatics 22: 323-331
Lee, J-Y., Baum, S.F., Oh, S-H., Jiang, C-Z., Chen, J-C. and J.L. Bowman. 2005. Recruitment of CRABS CLAW to promote nectary development within the eudicot clade. Development 132: 5021-5032
Lee J-Y., Levesque M. and P.N. Benfey. 2005. High-throughput RNA isolation technologies: New tools for high-resolution gene expression profiling in plant systems. Plant Physiol. 138: 585-590
Nawy, T., Lee, J-Y., Colinas, J., Wang, J.Y., Thongrad, S.C., Malamy, J.E., Birnbaum, K. and P.N. Benfey. 2005. ranscriptional profile of the Arabidopsis root quiescent center. Plant Cell 17: 1908-1925
Lee, J-Y., Baum, S.F., Alvarez, J., Patel, A., Chitwood, D.H. and J.L. Bowman. 2005. Activation of CRABS CLAW in the Nectaries and Carpels of Arabidopsis. Plant Cell 17: 25-36
Mummenhoff, K., Linder, P., Friesen, N., Bowman, J.L., Lee, J-Y. and A. Franzke. 2004. Molecular evidence for bicontinental hybridogenous genomic constitution in Lepidium sensu stricto (Brassicaceae) species from Australia and New Zealand. Am. J. Bot 91: 254-261
Lee, J-Y, Bowman J.L. and K. Mummenhoff. 2002. Allopolyploidization and evolution of species with reduced floral structures in Lepidium L. (Brassicaceae). Proc. Natl. Acad. Sci. USA 99: 16835-16840
Bowman, J.L., Y.Eshed, S.F. Baum, J.F. Emery, S.K. Floyd, J. Alvarez, N.P. Hawker, J-Y, Lee, K.R. Siegfried, R. Khodosh, M. Tatom-Jaurez and J.V. Perea. 2001. The story of CRABS CLAW (or How we learned to love the mutagen). Flowering Newsletter 31: 3-11
Bowman, J.L., H. Brüggemann, J-Y. Lee and K. Mummenhoff. 1999. Evolutionary changes in floral structure within Lepidium L. (Brassicaceae). Int. J. Plant Sci 160: 917-929
Lab Members
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